D3 NUTRITION is a dietary supplement containing Vitamin D3 (4000 IU/100 mcg per pearl)
Vitamin D is extremely important for the proper functioning of our body, however, there are very few sources of it in nature. The main source of Vitamin D remains the sun; during exposure to the rays, in fact, our body synthesizes sunlight, transforming it into a nutrient essential for bone structure. Vitamin D occurs as a regulator of blood calcium levels and is important for blood pressure itself and for stabilizing glucose levels. According to latest research, Vitamin D is reported to influence our mood and mental health.
Vitamin D also supports thyroid health and is important for a healthy pregnancy, promotes gut balance and immune function, and influences brain development and function. In light of these findings, a significant volume of research has examined the link between vitamin D status, how low or high levels are in the blood, concluding that an increase in circulating vitamin D can have a significant impact on health.
Despite this, about 30 percent of adults do not get the right amount throughout the day. In fact, in nature, besides the sun, the only effective and substantial plant source of vitamin D is mushrooms. Mushrooms, just like our bodies, have the ability to absorb sunlight and convert it into vitamin D2. This type has the same properties as the usual vitamin D, it is simply synthesized in a different form. Our bodies, like those of animals, convert sunlight into vitamin D3. In any case, the substance taken in through the consumption of vegetables, remains limited in any way. For this reason it is important to take vitamin D3 supplements.
VITAMIN D:
- Contributes to normal absorption/utilization of calcium and phosphorus;
- Contributes to normal blood calcium levels;
- Contributes to the maintenance of normal bones;
- Contributes to the maintenance of normal muscle function;
- Contributes to the maintenance of normal teeth;
- Contributes to normal immune system function;
- Intervenes in the process of cell division.
Vitamin D for bones and teeth:
The most important physiological function of Vitamin D is to regulate the amount of calcium in the body. Specifically, it stimulates the absorption of calcium in the gut by increasing its levels in the blood; Calcium is essential for the development and health of bones and teeth, so adequate absorption is essential.
Vitamin D for muscles and tendons:
Vitamin D receptors are present in muscle cells and their expression tends to decrease with advancing age. Vitamin D stimulates muscle protein production, but more importantly it activates certain calcium transport mechanisms at the sarcoplasmic reticulum, which are essential in muscle contractions. Under conditions of hypovitaminosis, pictures of myopathy of the proximal muscles of the limbs (e.g., difficulty in getting up from a chair, other functional difficulties), sarcopenia (the loss of muscle mass), the reduction of muscle strength, with disturbances in balance and resulting in an increased risk of falls and fractures are often described.
Recently, a hypovitaminosis of Vitamin D has been found to affect functional recovery in the post-fracture period of the femur. The two basic components of tendons are an elastic fibrillar part, composed mainly of collagen, and a cellular part, represented by tenocytes, which is involved in collagen production.
Vitamin D acts on the tenocytes by promoting the production of collagen fibers.
In this way, it ensures the adequate strength and elasticity characteristics essential for tendons to perform their function.
Vitamin D and immunity:
Vitamin D has a modulating action toward the immune system by activating T lymphocytes, i.e., the cells charged with recognizing foreign bodies, making them more sensitive and strong in the fight against viruses and bacteria. Many studies associate low vitamin D levels with increased infections, and there is also growing epidemiological evidence linking vitamin D deficiency and autoimmune diseases including multiple sclerosis, rheumatoid arthritis, diabetes mellitus, inflammatory bowel disease, and systemic lupus erythematosus.
It is known that macrophages (the first defense cells that are part of the immune system) recognize lipopolysaccharide LPS, a surrogate for bacterial infection, through toll like receptors (TLRs). Involvement of TLRs leads to a cascade of events that produce substances with potent bactericidal activity such as catheloidin and beta-defensin. The production of these molecules with antimicrobial activity is stimulated by the presence of the active form of Vitamin D on its receptor present on the membrane of macrophages. Vitamin D thus plays an important role in the innate antimicrobial response, entering at the forefront of this mechanism involving macrophages, receptors, bacteria and viruses.
Vitamin D and inflammation:
Recent studies have shown an association between low vitamin D levels and increased levels of inflammatory markers. Several studies also show an inverse association between vitamin D levels and the concentration of two proteins involved in the inflammatory process, E-selectin and c-reactive protein, a finding that suggests an anti-inflammatory action of vitamin D even in healthy subjects.
It is inferred from these data that vitamin D exerts a strong anti-inflammatory action at the gut and systemic levels. In addition, in subjects with hypovitaminosis D there was an increased predominance at the level of the intestinal microbiota of gram-negative bacterial strains that are potentially pathogenic and promoters of infectious processes.
Vitamin D and tumors:
Laboratory studies have shown that vitamin D has an activity potentially capable of preventing or slowing the development of cancer: in fact, it restrains the growth of cells, promotes their differentiation and programmed death (apoptosis), and reduces the formation of new vessels (angiogenesis).
Vitamin D and microbiota:
The composition of the gut microbiome varies with the level of vitamin D intake and the concentration of its biologically active form, 25-hydroxy vitamin D (25(OH)D). This was demonstrated by researchers at the University of São Paulo, Brazil, who conducted a study of 150 healthy individuals, divided into 3 groups based on vitamin D levels. Of the study participants, the inflammatory profile and composition of the gut microbiome were also analyzed, given the role played by this vitamin in modulating the immune system precisely at the enteric level.
According to some studies, a deficiency of it would be able to deteriorate the intestinal side, promoting the translocation of endotoxins into the circulatory stream and the development of a systemic inflammatory state. Furthermore, it has been hypothesized that the relationship between vitamin D and some metabolic diseases may be mediated by the composition of the intestinal bacterial population. Brazilian researchers therefore decided to test whether the hypothesized link between levels of this vitamin and the microbiome depends on a low-grade inflammatory state. From the data, published in the journal Metabolism, it appears that lipopolysaccharide (LPS) concentration increases concomitantly with 25(OH)D reduction. Analysis of stool samples then showed that the group of subjects with higher vitamin D levels is characterized by the abundance of certain bacterial strains, such as Prevotella, and the scarcity of others, including the gramnegative Haemophilus and Veillonella. The researchers also found an inverse association between 25(OH)D levels and the concentration of two proteins involved in the inflammation process (E-selectin and c-reactive protein), a finding that suggests an anti-inflammatory action of vitamin D even in healthy subjects.
Based on the data obtained, the researchers therefore concluded that vitamin D’s ability to modulate immune system activity in the gut may influence the composition of the microbiome. It is therefore more than necessary to investigate the Vitamin D3 – VDR Polymorphism – Gut Microbiota relationship in all possible venues in order to provide timely and effective answers with targeted intervention on all autoimmune diseases, starting with inflammatory diseases of the colon.
Vitamin D and diet:
Some scientific studies have shown that vitamin D also has “slimming” power: the ratio of fat mass to lean mass is balanced in subjects who have high doses of vitamin D in their blood. These subjects turn out to be normal weight and do not tend to gain weight while those who are overweight and obese have very low vitamin D values in their blood. Basically, this vitamin helps to lose weight because it stimulates leptin, a particular hormone that reduces hunger and increases satiety. It also reduces the formation of protein molecules such as cytokines, which are responsible for the formation of fat, especially abdominal fat.
Another research published in the Nutrition Journal states that increasing vitamin D intake leads to a reduction in body fat percentage. This is mainly because vitamin D influences the storage and production of fat in the body and impacts other hormones (such as testosterone) and neurotransmitters (such as serotonin) in the body. While testosterone is known to reduce body fat and promote weight loss by increasing metabolism and blocking the formation of new fat cells, serotonin can reduce appetite and caloric intake by making people satiated for longer and also regulating sleep patterns.
Vitamin D and hair:
Vitamin D3 is produced by our skin and, therefore, the receptor is also found in hair follicles. Specifically, studies have highlighted the role of this vitamin in initiating the active phase of the hair life cycle (anagen). It has also been noted that in cases of androgenetic alopecia there is often a deficiency of vitamin D, which is why it is also important for hair health that this is present in our bodies.
Finally, it is possible to report what are the results of some very important studies, which highlight the role of vitamin D in hair growth. It has also been noted that in cases of androgenetic alopecia there is often a deficiency of vitamin D, and that is why it is also important for hair health that this is present in our bodies.
Vitamin D and erectile dysfunction:
According to the latest research on the relationship between vitamin D and the health of the sexual system in men, it appears that having normal levels of vitamin D in the blood can help prevent erectile dysfunction, an issue that is becoming increasingly common even among young patients. Adequate levels of vitamin D, in fact, are critical for maintaining a healthy cardiovascular system, bringing direct benefits to men’s sexual health and activity as well.
The relationship would be due to the fact that cardiovascular disease and erectile dysfunction share many risk factors, such as diabetes, high cholesterol levels, cigarette smoking habit, hypertension, overweight, and depression. In particular, vitamin D plays a positive role in the production of nitric oxide, which is the most important factor promoting the dilation of arterial vessels not only in the heart and different vascular districts but also in the penis, promoting erection. For this reason, if there is a vitamin D deficiency, there is a higher risk of developing cardiovascular disease, which, as a result, potentially endangers the health of the male sexual system. If, on the other hand, vitamin D levels are adequate, the likelihood of developing both cardiovascular disease and erectile dysfunction should be reduced, although studies on an adequate number of patients are still needed.
Vitamin D and Parkinson’s disease:
In a study of 182 patients with Parkinson’s disease (PD) and 185 healthy controls, patients with PD had significantly lower serum vitamin D levels than healthy controls. In addition, PD patients with lower vitamin D levels had a significantly higher frequency of falls, insomnia, depression and anxiety. Finally, PD patients also had significantly lower mean BMD (bone minerai density) of the lumbar spine and femoral neck. In PD patients, vitamin D levels were significantly related to falls and some non-motor symptoms.
(“Relationship between 25-hydroxyvitamin D, bone density and symptoms of Parkinson’s disease Hui-Jun Zhang , Jin-Ru Zhang , Cheng Jie Mao , Kai Li , Fen Wang , Jing Chen , Chun-Feng Liu“)
Nutritional table
| Medium Contents | Per daily dose |
|---|---|
| Fish oil provides Omega 3:
EPA (eicosapentaenoic acid) DHA (docosahexaenoic acid) |
175 mg 125 mg |
| Vitamin D3 (Cholecalciferol) | 50 mcg (2000 UI) (1000 % VNR*) |
FORMAT
Jar of 90 pearls of 1,33 g.
WEIGHT
119,7 g.
INGREDIENTS
Fish oil (from sardines, herring, mackerel) containing Omega 3 fatty acids (EPA and DHA), shell: bovine gelatin, glycerin; Vitamin D3 (cholecalciferol).
METHOD OF USE.
1 pearl every other day.
WARNINGS
Keep out of reach of children under 3 years of age. Do not exceed the recommended daily dose. Store in a cool, dry place away from direct light. The minimum shelf life refers to the product in its unopened packaging, stored properly.
Food supplements should not be considered a substitute for a varied and balanced diet and a healthy lifestyle.
For further information on D3 nutrition, on the scientific studies that led to its formulation, on the scientific bibliography and on the properties of its main components, select the following button:
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