The Bioactive Collagen Peptides found in Colplus, are specifically for bone collagen regeneration. A highly controlled technology that helps regenerate collagen in general, but specifically the Peptides are recognized by bone cells that are stimulated to produce bone and extracellular matrix collagen. In addition, Peptides also act by reducing the process of bone degradation.
COLPLUS is a dietary supplement containing:
- Hydrolyzed Collagen (Bioactive Collagen Peptides);
- Vitamin C which contributes to normal collagen formation for normal bone function;
- Vitamin D which contributes to normal absorption/utilization of calcium and phosphorus and maintenance of normal bones.
The novelty of the new COLPLUS is in the enhancement of the formula;
COLPLUS 30 sachets contains:
- 1000 mg of Vitamin C and no longer 80 mg as previously;
- 50 mcg of Vitamin D and no longer 5 mcg as before;
- Bioactive Collagen Peptides specifically for bone collagen regeneration.
It is a highly controlled technology that helps regenerate collagen in general but specifically the Peptides are recognized by bone cells that are stimulated to produce bone and extracellular matrix collagen. In addition, the Peptides also act by reducing the process of bone degradation.
COLPLUS – BONE STRUCTURE AND THE ROLE OF COLLAGEN IN BONE
Bone consists of 70% minerals and 30% organic matrix. The organic matrix consists of 98% protein, of which 95% is collagen and 5% non-collagen (anist fundamental substance), while the remaining 2% of the organic matrix is composed of bone cells. The mineral component consists mainly of crystals of calcium and phosphorus salts (hydroxyapatite), as well as magnesium and other elements, deposited between the fibers of the bone matrix, which give bone its rigidity and strength.
The organic component, called the bone matrix, consists of a scaffold of protein fibers (mostly collagen) that give the entire structure cohesion, elasticity and strength. The cellular component comprises mainly three types of cells: osteoblasts (responsible for the formation and deposition of new bone), osteoclasts (responsible for the destruction and resorption of old bone) and osteocytes (which probably have an autonomous regulatory role in these two processes).
Collagen is essential for bone flexibility and elasticity and provides the structure for calcium mineralization; a weak collagen matrix provides insufficient calcium binding sites. Bioactive Collagen Peptides (BCPs) in COLPLUS can stimulate the metabolism of bone matrix cells (osteoblasts and osteoclasts) to increase the synthesis of bone components such as collagen: Bioactive Collagen Peptides are derived from a highly controlled production process: enzymes (endopeptidases) cut collagen at specific points; the short peptides thus formed have two unique characteristics: a very compact “helix tip” structure that allows their absorption in the intestine via paracellular transport and recognition by receptors (integrins) of collagen-producing cells that are thus stimulated to produce new collagen.
In practice, the specific peptides are recognized by the bone cells (osteoblasts) as the same collagen fragments as those resulting from catabolic activities, so they are stimulated to increase collagen metabolism to counterbalance the presumed degradation of collagen in bone.
The result is significantly increased production of bone collagen and extracellular matrix in general, replacing what has been lost due to various factors. In addition, Bioactive Collagen Peptides positively influence the process of bone degeneration by reducing the activity of osteoclasts.
Reduction of bone mass and microarchitectural deterioration of bone are the pathological conditions of osteoporosis (OP), which is characterized by deterioration of bone tissue, leading to increased fragility and consequent increased risk of fractures. Osteopenia, the initial stage of osteoporosis, can begin at age 35 where bone mass progressively decreases. The likelihood of having a fracture increases with age. The risk of having a bone fracture doubles every ten years in both sexes.
When menopause begins, estrogen deficiency significantly affects the process of bone remodeling, that is, the process by which old bone is replaced by new bone. The progressive decrease in bone mass, osteopenia, may constitute an early stage of osteoporosis: the systemic disease of the skeletal system characterized by low mineral density and deterioration of the micro-architecture of bone tissue, leading to increased bone fragility and consequent increased risk of fractures. The incidence of osteoporosis and related fractures increases with increasing age to affect one in three women over a lifetime. Osteoporosis can be prevented, diagnosed (before complications) and treated to reduce the risk of incurring a bill.
Nutritional Table
| INGREDIENTS | FOR 1 SACHET |
|---|---|
| FORTIBONE® (bovine hydrolyzed collagen) | 5 g |
| Vitamin C (L-ascorbic acid) | 1 g (1250% VNR*) |
| Vitamin D (cholecalciferol) | 50 mcg (1000 % VNR*) |
*VNR= Nutrient Reference Value.
FORMAT
30 7 g sachets of soluble powder.
INGREDIENTS
FORTIBONE® (bovine hydrolyzed collagen); “FORTIBONE® is a trademark of GELITA AG”), vitamin C (L-ascorbic acid), blood orange flavor, silica dioxide, mono- and diglycerides of fatty acids, sweetener: steviol glycosides, vitamin D (cholecalciferol).
METHOD OF USE.
1 sachet per day is recommended.
WARNINGS
Do not exceed the recommended daily dose. Keep out of the reach of children. Food supplements should not be intended as a substitute for a varied and balanced diet and a healthy lifestyle.
Store in a cool, dry place.
For further information on Colplus, on the scientific studies that led to its formulation, on the scientific bibliography and on the properties of its main components, select the following button:
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